The therapeutic effects of photobiomodulation (low level laser) treatment were first discovered by Endre Mester, a professor of surgery, who observed improved hair growth and healing in tissue adjacent to his laser surgery but where only a low laser dose was received.
His subsequent work provided the initial volume of evidence for the efficacy of laser in healing.
When cells get stressed (perhaps due to disease, injury or ageing) the mitochondria produces nitric oxide (NO). This competitively displaces oxygen from cytochrome c oxidase consequently reducing ATP (an essential intracellular cellular energy and extracellular signalling molecule) and causing an over production reactive oxygen species (ROS) and leading to oxidative stress.
Oxidative stress is well known to lead to inflammation and cell death via the gene transcription factor NF-Kb. Low Level Laser Therapy (LLLT) of the correct wavelength and density, dissociates NO allowing oxygen back in, so ATP is restored and oxidative stress reduced.
Once normal mitochondrial function is restored by LLLT then cell metabolism is improves, and the patient gets better more quickly.